Table of contents: (1) Objective and scope; (2) Introduction; (3) Engineered gene drives; (4) General risk assessment considerations for living modified organisms containing engineered gene drives; (5) Recommendation of acceptability of risk and identification of risk management strategies; (6) Monitoring; and (7) Related issues. Annexes: I (Further information on modelling); II (Further information on uncertainty); III (World Health Organization guidance framework for testing genetically modified mosquitoes; IV (Taxonomic classification of the Culicidae (mosquitoes)); V (Non-exhaustive list of mosquito vectors of diseases); VI (Current landscape for development of living modified mosquitoes containing engineered gene drives for disease vector control); VII (Engineered gene drive systems); and VIII (List of terms).